Significats de autophagic flux en anglès

Both CDT and IR concomitantly suppressed mTOR signaling and stimulated the autophagic flux.

Surprisingly high EGFR expressing cells display a lower autophagic flux.

Altogether, these results unveil the cellular process by which PA exposure impairs the autophagic flux.

Thus, efficient autophagic flux is required for healthy aging in many if not all eukaryotic organisms.

These results establish modulators of Atg4b-dependent autophagic flux as new potential targets in the treatment of HD.

Simultaneously, the antibiotic impaired lysosomal functions by blocking the autophagic flux, and this concurrence reduced cell viability.

Inhibition of PLD enzymatic activity and subsequent Akt activation decreases GBM cell viability by specifically inhibiting autophagic flux.

Fluorescence activated cell sorting and Western blotting experiments were used to evaluate the P140 effects on autophagic flux markers.

We further show that both autophagic flux and the recycling of lysosomes from autolysosomes were impaired in knockout cells.

Furthermore, in response to ND, YAP increased the autolysosome degradation, thereby enhancing the cellular autophagic flux in breast cancer cells.

This degradation is significantly attenuated in EC treated with ammonium chloride or chloroquine, which are lysosomal inhibitors that block autophagic flux.

Proper regulation of the autophagic flux is fundamental for the homeostasis of skeletal muscles in physiological conditions and in response to stress.

The resultant changes in myocardial levels of neddylated cullin 1 as well as autophagic flux in cardiac and brain tissues were assessed.

We show that loss of SQSTM1 causes impaired production of ubiquitin-positive protein aggregates in response to misfolded protein stress and decelerated autophagic flux.

Reactivation of the autophagic flux by either nutritional approaches or by pharmacological and genetics tools removes dysfunctional organelles and greatly ameliorates the dystrophic phenotype.

Experiments using EGFP-mRFP-LC3 provided further support for blockage of the autophagic flux at initiation stages upon SGPL1 deficiency due to PE paucity.