USA300 strains were differentiated by a stable chromosomalmutation in gyrA conferring quinolone resistance.
2
Bacterial chromosomalmutations that confer antibiotic resistance often have deleterious effects that impose costs on reproductive fitness.
3
The presence of genotoxic agents in the environment may cause chromosomalmutations through different mechanisms, which are associated with serious health effects.
4
This study therefore sought to identify chromosomalmutations and plasmid-mediated resistance as possible mechanisms of fluoroquinolone resistance from clinical isolates in Ghana.
5
Characterized mechanisms of colR in K. pneumoniae are largely due to chromosomalmutations in two-component regulators, although a plasmid-mediated colR mechanism has recently been uncovered.