Significats de downstream effector en anglès

However, many upstream signalling and downstream effector processes are only partially understood.

Here, we interrogated the downstream effector pathways of MET signaling in GSCs.

Dronc may play roles in dying cells in addition to activating downstream effector caspases.

Recently, we have shown that ER-bound transcription factor Crebh is a downstream effector of hepatic Cb1r signaling pathway.

These data establish Pak as a critical regulator of axon guidance and a downstream effector of Dock in vivo.

Here, we report that glucose, the ubiquitous energy source used for ATP generation, regulates the Hippo pathway downstream effector YAP.

However, blocking the small GTPase Rho or its downstream effector kinase, ROCK, partially reversed the effects of MAG on the neurons.

It is necessary for nutrient-mediated activation of the downstream effector S6K1 and increases in cell size.

This sphingosine-1-phosphate-induced increase was reduced by inhibition of sphingosine-1-phosphate receptor 2 or its downstream effector Rho-kinase.

Constitutively activating mutations in receptor kinases recruit downstream effector pathways independently of upstream signaling, with consequences ranging from developmental syndromes to cancer.

These results suggest that 14-3-3beta is a downstream effector of xCT in KS to mediate the cell proliferation.

In vivo functional studies of GPCR signaling are complicated not only by the need for specific spatiotemporal activation, but also by downstream effector promiscuity.

MARY-X should allow us to further dissect out both the upstream regulatory machinery and the downstream effector molecules responsible for the inflammatory carcinoma phenotype.

Western blot data demonstrated that compound 69407 suppressed phosphorylation of the MSK1 downstream effector histone H3 in intact cells.

CK2 was critical to the stabilization and activity of the transcription factor GLI2, a late downstream effector in SHH signaling.

To understand how H2A.Z participates in such diverse activities, we sought to identify downstream effector proteins that are recruited to chromatin via H2A.Z.