Significats de gelsolin en anglès

Renal biopsy followed by laser micro-dissection and mass spectrometry showed amyloidosis derived from gelsolin.

Following hemorrhagic shock, gelsolin levels decrease significantly, possibly due to consumption by the actin scavenging system.

Then, the effects of divalent metal ions on the ATP binding to plasma gelsolin were examined.

One of the proteins controlling actin dynamics is gelsolin, a calcium-activated actin filament severing and capping protein.

Clinically, reduced gelsolin concentrations have been associated with increased mortality in critically ill, trauma, and burn patients.

Villin is a gelsolin-like cytoskeleton regulator localized in the brush border at the apical end of epithelial cells.

Neither ADP nor GDP at up to 100 microM appreciably bound to gelsolin at a physiological salt concentration.

Evidence suggests that proteins belonging to the gelsolin superfamily may be involved in other processes, including gene expression regulation.

These observations are consistent with the calcium activation of F-actin severing by villin analogous to the gelsolin helix-straightening mechanism.

The results were validated in the bleomycin-induced animal model of pulmonary inflammation and fibrosis using genetically-modified mice lacking gelsolin expression.

Two distinct isoforms of the Ca-dependent actin filament severing protein gelsolin were identified in cross-striated muscles of the American lobster.

Genetic ablation of gelsolin protected mice from the development of modelled pulmonary inflammation and fibrosis attributed to attenuated epithelial apoptosis.

Follow-up of these cases might give us more insight into pathogenicity and potential treatment strategy of this atypical presentation of gelsolin amyloidosis.

Results: Increased gelsolin expression was detected in lung samples of patients with idiopathic interstitial pneumonia as well as in modelled pulmonary inflammation and fibrosis.

Moreover, to gain mechanistic insights into the mode of gelsolin activity, a series of biochemical analyses was performed ex vivo in mouse embryonic fibroblasts.

Higher levels of gelsolin and retinol-binding protein 4 were also found in the population with silent infarcts, both of which have been linked to stroke.