Significats de leukemic stem en anglès

We investigated whether leukemic stem cells in CML also use the beta-catenin pathway for self-renewal.

These results provide further evidence that BCR-ABL-transformed GMP with abnormal beta-catenin activity can function as leukemic stem cells.

So, a sparing effect of fractionation for lung tissue could be offset by a less effective leukemic stem cell kill.

It also confirms the persistence of leukemic stem cells in patients in deep molecular response, certainly at the origin of relapses.

This is primarily caused by resisting leukemic stem cells (LSCs), which prevent achievement of treatment-free remission in all patients.

Here we studied the ability of MSCs to support the growth and survival of leukemic stem cells (LSCs) in vitro.

Consequently, the occurrence of the so-called leukemic niche promotes both the proliferation of myeloid cells and the maintenance of quiescent leukemic stem cells.

More important, we must develop alternative treatment approaches, such as agents that target specific leukemia-associated abnormalities and agents that selectively eradicate leukemic stem cells.

Results: For identification of leukemic stem cells, we developed flow cytometric methods using leukemic stem cell associated markers and newly-defined (light scatter) aberrancies.

One resultant cell line studied in depth exhibits cellular properties characteristic of AML, notably a hierarchical organization initiated by leukemic stem cells that differentiate abnormally.

T-cell immunoglobulin and mucin domain 3 (Tim-3) is a checkpoint receptor expressed by a wide variety of immune cells as well as leukemic stem cells.