Significats de multicellular spheroids en anglès

We have formulated a mathematical model that predicts the extent and location of quiescence in multicellular spheroids.

In addition, multicellular spheroids grown from tumor cells and fibroblasts were exposed to 5-aminolevulinic acid and analyzed accordingly.

Though reported limitedly in tissue engineering, modification of cellular functions can be achieved by culturing them into multicellular spheroids.

Adult rat hepatocytes are capable of assembling to form floating multicellular spheroids (spheroids) in a dish with a positively charged surface in primary culture.

Statement of significance: Multicellular spheroids and microtissues are valuable for tissue engineering, but fabrication approaches typically sacrifice either precision or throughput.

Multicellular spheroids generated through cellular self-assembly provide cytoarchitectural complexities of native tissue including three-dimensionality, extensive cell-cell contacts, and appropriate cell-extracellular matrix interactions.