Diagnosis of MCI was made according to the MDS criteria level II.
2
Methods: CC and FISH analyses were conducted for 216 primary MDS patients.
3
Clinical studies have demonstrated that decitabine has activity in patients with MDS.
4
Responses and outcomes were standardised according to the International Working Group MDS criteria.
5
A few recent case-control studies suggest an association between MDS and several occupations.
1
We report two THC2 patients misdiagnosed with myelodysplasia and treated with chemotherapy.
2
Cytopenia at day 30 was not significantly associated with later diagnosis of myelodysplasia.
3
Bone marrow biopsy done 3 months prior showed no significant myelodysplasia or lymphoid aggregates.
4
Results in myelodysplasia and aplastic anemia have been less encouraging.
5
However, there are very limited data on the development of hemophagocytosis or myelodysplasia in these patients.
1
Ten patients with preleukemia and life-threatening pancytopenia were treated with marrow transplantation.
2
Specimens were obtained from patients with preleukemia and associated antigen weakening, and from individuals with normal antigen values.
3
This experience also emphasizes the importance of performing chromosome studies before transplantation for pancytopenic states in order to identify cases of preleukemia.
1
A myelodysplasticsyndrome was noted 83 months from the start of therapy.
2
With these techniques, we studied a 61-year-old woman with a myelodysplasticsyndrome.
3
Case reports: A 76-year-old male with a known myelodysplasticsyndrome presented with pneumonia.
4
Additionally, two patients with primary mediastinal germ cell cancer developed a myelodysplasticsyndrome.
5
Sixteen children with myelodysplasticsyndrome as defined by the French-American-British co-operative group are presented.
Ús de myelodysplastic syndromes en anglès
1
Acute myeloid leukemia and myelodysplasticsyndromes represented the most common disease indications.
2
Objective: Unbalanced chromosomal aberrations are common in myelodysplasticsyndromes and have prognostic implications.
3
All patients belonged to the more aggressive subtypes of myelodysplasticsyndromes.
4
The relationship between these cytopenias and myeloid neoplasms like myelodysplasticsyndromes is currently poorly defined.
5
Results: Many rare germline mutations have been identified that lead to acute leukemia and myelodysplasticsyndromes.
6
The other subset has cytogenetic abnormalities similar to those in myelodysplasticsyndromes and a poor prognosis.
7
Selecting the most appropriate treatment for patients with myelodysplasticsyndromes (MDS) requires careful consideration of several factors.
8
Some of these factors have been studied and used in chemotherapy-induced neutropenia, myelodysplasticsyndromes, and bone marrow failure syndromes.
9
Some drugs can home in on these changes however -notably drugs used to treat myelodysplasticsyndromes, sometimes known as pre-leukemia.
10
The International Prognostic Scoring System has been revised (IPSS-R) to predict prognosis of patients with myelodysplasticsyndromes at diagnosis.
11
In patients with myelodysplasticsyndromes and symptomatic anemia, we evaluated the safety and hematologic activity of lenalidomide, a novel analogue of thalidomide.
12
Celgene will acquire Vidaza, approved in the United States for myelodysplasticsyndromes, a group of blood disorders that can lead to leukemia.
13
The myelodysplasticsyndromes (MDS) are heterogeneous clonal disorders of ineffective hematopoiesis characterized by limited treatment options and a poor prognosis.
14
DNA flow cytometric analysis of unfixed bone marrow cells stained with propidium iodide was carried out in 33 patients with untreated primary myelodysplasticsyndromes.
15
In congenital neutropenia, the inherent risk of developing myelodysplasticsyndromes or AML requires careful monitoring, including routine blood counts and annual bone marrow examinations.
16
Cyclacel is now focusing its clinical development priorities on sapacitabine in acute myeloid leukemia in the elderly, in myelodysplasticsyndromes and in cutaneous T-cell lymphoma.