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Significats de nrti en anglès
An antiviral drug used against HIV; is incorporated into the DNA of the virus and stops the building process; results in incomplete DNA that cannot create a new virus; often used in combination with other drugs.
Veure'n mésÚs de nrti en anglès
1
The only factor associated with mtDNA depletion was duration of NRTI use.
2
Two children had baseline NRTI and PI mutations, suggesting previous maternal ART.
3
Morbidity and mortality were not changed by the addition of dual NRTI therapy.
4
Differences in drug-resistance patterns in both NRTI and NNRTI were observed by site.
5
NRTI phosphorylation seems to correlate with mitochondrial toxicity, but experimental evidence is lacking.
6
We explored the relationships between oxidant stress and NRTI-induced peripheral neuropathy.
7
We assessed the safety and activity of regimens that did not include an NRTI.
8
Twelve of the 18 patients modified their NRTI regimen at the time ritonavir-saquinavir was initiated.
9
Forty-one per cent of patients discontinued their NRTI-sparing regimen.
10
An in vitro assay to predict mitochondrial toxicity of in-use and developmental NRTI would be invaluable.
11
These compounds are effective against many NRTI drug-resistant RT variants; however, the M184V mutant is relatively resistant.
12
Maximal power output was diminished and anaerobic threshold occurred earlier in HIV-infected patients, regardless of NRTI exposure.
13
Here, analysing a large database, we report the selection of another rare K65E mutation in patients failing on NRTI-containing regimens.
14
The in vitro assay described here might be used to predict the mitochondrial toxicity of other NRTI, alone or in combination.
15
More extensive studies of mtDNA mutation at the single molecule level are required to correlate mitochondrial dysfunction with NRTI-caused molecular defects in mtDNA.
16
All laboratories measured protease inhibitors, most measured at least 1 non-nucleoside reverse transcription inhibitor and 5 had NRTI capabilities.
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