Significats de pharmacokinetic model en anglès

The pharmacokinetic model favours once per day dosing with adjustment for weight.

The pharmacokinetics could be described by an open 2-compartment pharmacokinetic model.

Cetuximab concentrations were described using a 2-compartment population pharmacokinetic model.

A pharmacokinetic model and a BE were developed using an iterative two stage Bayesian approach.

Data analysis was performed with a population pharmacokinetic model with a description of autoinduction of ifosfamide.

A population pharmacokinetic model was developed to describe nelfinavir-M8 concentration time-courses and to estimate interpatient variability.

The platform supports pharmacokinetic model-informed dosing guidance and has functionality to incorporate real-time drug concentration information.

A population pharmacokinetic model was developed using non linear mixed effects modelling techniques, utilizing the software NONMEM.

None of the tested covariates was found to be correlated with any of the pharmacokinetic model parameters.

Anti-factor Xa levels were obtained, and a published population pharmacokinetic model for fondaparinux was fit to the data.

The MRI data were acquired with a turbo fast low-angle shot sequence and analyzed using a pharmacokinetic model.

In the pharmacokinetic model, weight and total bilirubin level were found to be significant predictors of tigecycline clearance.

The resultant data provided the framework to develop a hybrid physiologically based pharmacokinetic model for temozolomide in brain.

A previously described population pharmacokinetic model was used to calculate the maximum a posteriori Bayesian estimates for 187 patients.

For the Bayesian approach a three-compartment population pharmacokinetic model was developed; optimal time-points were selected using the D-optimality algorithm.

Objectives: To develop a population pharmacokinetic model suitable for Bayesian estimation of individual AUC in stable renal transplant patients.