Significats de proteasomal degradation en anglès

We demonstrate that gigaxonin is crucial for ubiquitin- proteasomal degradation of neuronal IF.

However, the molecular mechanism regulating proteasomal degradation of the Klf4 is poorly understood.

Proteins regulating proteasomal degradation were stably increased in response to spinal cord injury.

Decreased abundance of Wip1 during mitosis is caused by proteasomal degradation.

SP is less stable than Rec as it is subjected to proteasomal degradation.

The ΔF508-CFTR mutant is recognized as improperly folded and targeted for proteasomal degradation.

We discovered that lethal factor induces cell death via the N-end rule proteasomal degradation pathway.

PHDs are the main cellular oxygen sensors and regulate HIF proteasomal degradation in an oxygen-dependent manner.

Differently linked polymers of polyubiquitin have been found that modify proteins without targeting to proteasomal degradation.

The majority of T162 mutant protein accumulates in the ER and is delivered to ER-associated proteasomal degradation.

Recent studies reveal that proteasomal degradation system is also involved in signal transduction and regulation of various cellular functions.

Suppression of virus-induced interferon levels was dependent on SOCS1 nuclear translocation but independent of proteasomal degradation of transcription factors.

We subsequently showed that UBXN2A increases proteasomal degradation of mot-2.

The Hippo pathway was deregulated in BAP1-deficient pancreatic tumors, with the tumor suppressor LATS exhibiting enhanced ubiquitin-dependent proteasomal degradation.

This effect is partially reversed by leupeptin or MG132, indicating that both the lysosomal and proteasomal degradation pathways are involved.

Here we leverage this strategy to develop a new class of small molecule antivirals that induce proteasomal degradation of viral proteins.