1Furthermore, classical activin signaling via Smad proteins is necessary for this synergy.
2These findings provide a new model of regulation of TGF-β-Smad signaling by TTF-1.
3We show that activin-A-induced phenotype is mediated by SMAD signaling pathway.
4Western blot analysis was used to detect Smad 2 protein.
5SMAD3 is one of the receptor-activated SMADs which are important in TGF-beta signal transduction.
6RAS involvement in NSF is unclear compared to transforming growth factor beta and Smad.
7This region contains an atypical nucleotide recognition element for the Smad family of transcriptional regulators.
8The mechanism that limits Smad-mediated processing to a selective group of miRNAs remained hitherto unexplored.
9The Ski family of nuclear oncoproteins represses TGF-beta signaling through interactions with the Smad proteins.
10These results suggest an interdependent relationship between the JNK and SMAD pathways in TGF-beta-mediated transcription.
11This repression is transmitted through TGF-beta signaling and can be regulated by other Smad proteins.
12Smad proteins have been identified as major components in the intracellular signaling of TGF-beta family members.
13Smad Place dazzled under forceful Wayne Hutchinson tactics to win the Hennessy Gold Cup at Newbury.
14Western blot and RT-PCR analyses were then used to detect Smad 7 protein and mRNA expression levels.
15His other big days included winning the Hennessy on Smad Place and a Scottish National on Godsmejudge.
16We propose that this highly conserved five-residue NLS motif determines ligand-induced nuclear translocation of all pathway-specific Smads.