Significats de specific enhancer en anglès

Furthermore, we identified a more distal stage- specific enhancer region also containing silencer elements.

We identified a robust hindlimb- specific interaction between Pitx1 and a putative hindlimb- specific enhancer.

Luciferase assays confirmed the allele specific enhancer activity for the BGALT5 and TKT loci.

We showed that rs16969681 lies in a region of active chromatin with allele- and tissue- specific enhancer activity.

Expression of the apolipoprotein AI (apoAI) gene in the liver is controlled by a liver- specific enhancer.

Moreover, analysis of TEC specific enhancer elements identified candidate transcription factors likely to be important in mTEC development and function.

In HHV-6 infected cells, this change in the genomic footprinting pattern is concomitant with the induction of specific enhancer-binding proteins in the nucleus.

Our studies identified a role for MyoD1 in condition- specific enhancer assembly through recruitment of transcription factors and histone-modifying enzymes that shape muscle differentiation.

We further replicated the allelic- specific properties for SNP rs7903146 in pancreatic beta cells and additionally demonstrate identical allelic- specific enhancer effects in other cell lines.

Suppression by oncostatin M involves activated STAT5 and requires an inhibitory element in the renin promoter that functions separately from cell type- specific enhancer elements.

We have recently identified and cloned a human transcription factor, TCF-1, that binds to a functional element in the T lymphocyte- specific enhancer of CD3-epsilon.

Conclusions: The transcription factor ERG promotes endothelial homeostasis via regulation of lineage- specific enhancers and super-enhancers.

We demonstrated that CHD1 occupied prostate- specific enhancers enriched for the androgen receptor (AR) and lineage-specific cofactors.

Interactome maps connecting disease-risk variants in cell-type- specific enhancers to promoters revealed an extended microglia gene network in AD.

Liver- specific enhancers were observed to be methylated in cortex, while cortex specific enhancers were methylated in the liver.

However, cell class- specific enhancers are distinguished by enrichment of E-box motifs in bipolar cells, and Q50 homeodomain motifs in photoreceptors.