1 Furthermore, classical activin signaling via Smad proteins is necessary for this synergy.
2 These findings provide a new model of regulation of TGF - β- Smad signaling by TTF-1.
3 We show that activin-A-induced phenotype is mediated by SMAD signaling pathway.
4 Western blot analysis was used to detect Smad 2 protein.
5 SMAD3 is one of the receptor-activated SMADs which are important in TGF-beta signal transduction.
6 RAS involvement in NSF is unclear compared to transforming growth factor beta and Smad .
7 This region contains an atypical nucleotide recognition element for the Smad family of transcriptional regulators.
8 The mechanism that limits Smad - mediated processing to a selective group of miRNAs remained hitherto unexplored.
9 The Ski family of nuclear oncoproteins represses TGF-beta signaling through interactions with the Smad proteins.
10 These results suggest an interdependent relationship between the JNK and SMAD pathways in TGF-beta-mediated transcription.
11 This repression is transmitted through TGF-beta signaling and can be regulated by other Smad proteins.
12 Smad proteins have been identified as major components in the intracellular signaling of TGF-beta family members.
13 Smad Place dazzled under forceful Wayne Hutchinson tactics to win the Hennessy Gold Cup at Newbury.
14 Western blot and RT-PCR analyses were then used to detect Smad 7 protein and mRNA expression levels.
15 His other big days included winning the Hennessy on Smad Place and a Scottish National on Godsmejudge.
16 We propose that this highly conserved five-residue NLS motif determines ligand-induced nuclear translocation of all pathway-specific Smads .
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