1
A solid phase-assisted synthetic approach was used to optimize the 3'-amide functionality.
2
TmlU was thought to be the sole enzyme responsible for this amide-bond formation.
3
This enzyme catalyzes deamidation of the side-chain amide group of asparagine in proteins.
4
Trypsin is specific for the hydrolysis of amide linkages of lysine.
5
The largest boost in activity was achieved by N-methylation of the C2-ethyl amide group.
6
A set of 18 amide derivatives of oleanolic or maslinic acid has been semi-synthesised.
7
We conducted a phenotypic screen and identified a micromolar hit with novel amide structure.
8
The latter is further connected via an amide bond to an unusual aliphatic acyl chain.
9
Careful selection of the amide substituent can also provide for analogues with modest gelatinase inhibition.
10
NMR spectra and rates of amide proton exchange showed that F2 fluctuates rapidly between several conformations.
11
The effect of cannabinoid agonists was mimicked by endocannabinoid uptake or fatty acid amide hydrolase inhibitors.
12
However, this reaction also leads to oligomers with a vast sequence diversity of ester and amide linkages.
13
However, amide protons are found to contribute only a small amount to the relaxivity at high pH.
14
To identify some underlying principles, we investigate the thermal diffusion of small amide molecules in water systematically.
15
We synthesized six new amide ezetimibe analogs.
16
The proposed mechanism is analogous to thioesterase-catalyzed chemistry, but the substrates are amide bonds rather than thioesters.
