Meanings of constant region in English

CSR changes the IgH constant region for an alternate set that confers distinct antibody effector functions.

A total of 17 different mAbs were obtained, which recognized the rIgE heavy chain constant region.

Chimeric mAbs containing human IgG2 constant region domains could be of particular value for certain radioimmunotherapeutic applications.

The SSK41 line contains a single immunoglobulin heavy-chain locus, the constant region (C) genes of which retain the germline configuration.

Infliximab is a chimeric monoclonal antibody composed of a human IgG1 constant region and a murine variable region and is administered intravenously.

Class switch recombination (CSR) is a region-specific DNA recombination reaction that replaces one immunoglobulin heavy-chain constant region (Ch) gene with another.

A constant region gene (C) of the immunoglobulin heavy chain can be transcribed as germline transcripts from a promoter located upstream of a switch region.

We report a method to generate bifunctional antibodies by grafting full-length proteins into constant region loops of a full-length antibody or an antigen-binding fragment (Fab).

A second (T8 or T4) serves as an associative recognition structure for a constant region of the class I or class II molecule.

The variable region genes of the mAb 29 were fused to human constant region genes, to form the chimeric 29 antibody (cAb 29).

Our study focused on the effect of delayed boosting in humans on the vaccine-induced Env constant region 1 and 2 (C1C2)-specific antibody repertoire.

Two-round amplifications using primers derived from CDRs and joining or constant regions were performed for MRD detection.

Tetrahymena actin diverges not only in relatively variable regions of other actins, but also in relatively constant regions.

Chicken Fab fragment libraries are constructed using human constant regions, facilitating detection with readily available reagents as well as humanization.

The variable and constant regions of the ImmunoBody are also flanked by restriction sites, which permit easy exchange of other IgG subtypes.

Typically, "deimmunized" antibodies are created with human constant regions and by expression of genes encoding these antibodies in mammalian cells.