Meanings of design limitation in English

Authors' conclusions: We identified relatively few, mostly small studies with short-term follow-up and design limitations.

Careful review of published trials of these interventions reveals design limitations that contributed to their inconclusive findings.

When the vibrations are dampened, the resulting motion is kept within the design limitations of the structure of the aircraft.

Among the possible design limitations of CAR-T cells for cancer are unwanted tonic (antigen-independent) signaling and off-target activation.

We emphasize the linking of clinical results to molecular mechanisms, discuss study design limitations, and offer some recommendations for future directions.

The report said the plane broke up as a result of "rudder flutter" because the aircraft airspeed exceeded the design limitations.