Meanings of elite controllers in English

Recent findings: The persistent HIV reservoir in elite controllers has two main implications.

Conclusions: HIV-1 Pol function seemed to be compromised in elite controllers.

This study examines whether similar functional defects occur in Pol proteins of elite controllers.

Mechanisms responsible for natural control of human immunodeficiency type 1 (HIV) replication in elite controllers (EC) remain incompletely defined.

Studies of these " elite controllers", which aim to find an AIDS vaccine, have so far concentrated on north America.

Certain HLA class I alleles are markedly enriched in elite controllers, with the highest association observed for HLA-B57 (ref.

Purpose of review: This review aims to summarize literature relevant to the management of elite controllers for clinicians caring for patients living with HIV.

First, increased immune activation appears to adversely impact clinical outcomes in elite controllers, but the role of ART in addressing this effect remains unclear.

Previous studies have shown that elite controllers with minimal effector T cell responses harbor a low-frequency, readily expandable, highly functional, and broadly directed memory population.

Methods: We describe 11 ART-naive elite controllers from 10 cohorts of HIV-infected children being followed in South Africa, Brazil, Thailand, and Europe.