We hypothesized that PKP2 may regulate focaladhesion dynamics and cell migration.
1
Background: FAK localization to focaladhesions is essential for its activation and function.
2
Assembly and modulation of focaladhesions during dynamic adhesive processes are poorly understood.
3
Vinculin was identified as a component of focaladhesions and adherens junctions nearly 40 years ago.
4
Stress fibers and focaladhesions are complex protein arrays that produce, transmit and sense mechanical tension.
5
This results in a net increase in active Rho, and increased stress fibers and focaladhesions.
1
Nonetheless, focalcontact proteins are central to mechanisms that regulate skin cell motility.
2
These results implicate the peptide segment nearest to the transmembrane region in focalcontact localization.
3
Interaction between individual FNIII domains and beta1 integrins mediates focal adhesion kinase phosphorylation and subsequent stress fiber and focalcontact formation.
4
Remarkably, both focalcontact and hemidesmosomal proteins appear involved in determining the speed and directional migration of epidermal cells by modulating several signal transduction pathways.
5
PKC delta EC contained significantly greater numbers of focalcontacts per cell.