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Here, we studied bioenergetics in an inducedpluripotentstemcell-based model of the disease.
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These findings were supported by differentiation experiments using BOS patient-derived inducedpluripotentstemcell lines.
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Nanog facilitates embryonic stem cell self-renewal and inducedpluripotentstemcell generation during the final stage of reprogramming.
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Human embryonic stem cells and especially patient specific inducedpluripotentstemcell-derived cardiomyocytes are well established as cardiac disease model..
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Here we report the generation of a human inducedpluripotentstemcell line from a BA patient using episomal vectors.
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Using cell surface capture technology, the cell surface N-glycoproteome of human- inducedpluripotentstemcell derived hepatic endoderm cells was assessed.
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This was verified in prefrontal cortex and - inducedpluripotentstemcell-derived neurons for the L-type calcium channel (CACNA1C) risk locus.
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They said they are now working to generate the so-called inducedpluripotentstemcell or iPS cells to match a variety of diseases.
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The epigenetic dynamics of inducedpluripotentstemcell (iPSC) reprogramming in correctly reprogrammed cells at high resolution and throughout the entire process remain largely undefined.
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Inducedpluripotentstemcell (iPSC) models of HD provide an opportunity to study the mechanisms underlying disease pathology in disease-relevant patient tissues.