Context: Oral naltrexone can completely antagonize the effects produced by opioid agonists.

An alternative is the use of a sustained release preparation of naltrexone.

Objective: To determine whether low-dose naltrexone is an effective treatment for Hailey-Hailey disease.

Active treatment was first a single 100-mg dose of naltrexone hydrochloride.

Those receiving naltrexone - with or without exposure therapy - benefited the most.