A rare brain and spinal cord disease caused by a virus and usually seen only in immunocompromised individuals, such as those with HIV.
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Last month Biogen said a fourth patient in Europe had developed PML.
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However, the basis for such a structural role of PML is unknown.
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The average number of infusions received before diagnosis of PML was 25.
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In particular, PML and p53 showed considerable potential as independent prognostic markers.
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Dozens of patients undergoing treatment with Tysabri have been diagnosed with PML.
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Four cases of PML have been diagnosed since the drug was reintroduced.
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The PML gene was rarely mutated and was not subject to LOH.
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Tysabri was withdrawn from the market in 2005 after three patients developed PML.
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Privately, military sources accused the PML-N of deliberately trying to undermine the army.
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Then, at the end of July, two more cases of PML were reported.
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Continued evaluation of anti-JCV antibody index and PML risk is warranted.
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We believe this is the first antemortem description of PML after liver transplantation.
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Survival of AIDS-related PML is improved by HAART when JCV replication is controlled.
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The PML tumor suppressor controls growth suppression, induction of apoptosis, and cellular senescence.
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PML mRNA was expressed in all tumor and cell line samples.
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PML degradation was also observed in SK-BR3 breast cancer cells treated with RA.