We also demonstrated that Sall1 and Mi2β exhibited a strong in vivo genetic interaction in the developing kidney.
2
When Mi2 function is compromised, persisting recombination intermediates are detected in late pachytene nuclei, indicating a failure in the timely repair of DSBs.
3
Intriguingly, our data indicate that in Mi2 mutant germ lines, a subset of DSBs are repaired by nonhomologous end joining, which manifests as chromosomal fusions.
4
We find that meiotic defects are exacerbated in Mi2 mutants lacking CKU-80, as evidenced by increased recombination intermediates, corpses, and defects in chromosomal integrity.
5
The MI2 has specifications that exceed those of the iPhone 4S and sells for less than half the price.
6
Procedure: Baits were distributed twice yearly in a 207-km2 (80-mi2) area in the vicinity of the Cape Cod Canal.