Main outcome measure: Symptoms of lifetime MD as assessed at personal interview.
2
I love English archetypes: public schoolboy, thirties, MD of his father's company.
3
Therefore, MIS may be a safe alternative to open surgery for MD.
4
Twenty-three cases had directly comparable areas of PD versus MD or WD.
5
Diagnosis of MCI was made according to the MDS criteria level II.
1
Strikingly, this amino acid alteration is the same as that seen in the mk mouse.
2
The corporation's job was done: MK was an economic and popular success.
3
MK: My approach is to always find something special, but still approachable.
4
MK opened offices in Japan and San Francisco to woo foreign companies.
5
Thus, our findings defined a role for LOX-PP in reducing MK ploidy.
1
Mutations in ATP7A can lead to the usually lethal Menkesdisease.
2
Menkesdisease is a very rare X-linked copper metabolism disorder that results from an ATP7A gene mutation.
3
Rapid diagnosis of Menkesdisease and early start of copper therapy is critical for the effectiveness of treatment.
4
With the advent of subcutaneous copper-histidine therapy, the early diagnosis of Menkesdisease becomes of utmost importance for patients' prognosis.
5
Menkesdisease is an X-linked recessive inherited disease caused by pathogenic variants in ATP7A, which leads to profound copper deficiency.
1
The neuropathologic abnormalities in three new cases of Menkes' kinkyhairdisease are described.
Uso de mnk en inglés
1
Our investigations revealed a MNK-controlled mechanism acting on mTORC2-AKT.
2
Herein, a structure-based virtual screening approach was performed to identify potential MNK inhibitors from natural products.
3
Compound 23 is the first highly selective dual MNK inhibitor targeting dysregulated translation being assessed clinically.
4
The hit compounds display activity in Mnk biochemical and cellular assays, including acute myeloid leukemia progenitors.
5
MNK-795 would have to be taken only once a day unlike other generic combinations in the market.
6
During the study, subjects took two tablets of MNK-795 every 12 hours.
7
Therefore we suggest that MNK-1 inhibition may present a new target to limit inflammation and remodelling in asthmatic airways.
8
Here, we report the development and application of a mutation-based induced-fit in silico screen to identify novel Mnk inhibitors.
9
We are the first to report that MNK-1 controls chemokine secretion and proliferation in human airway smooth muscle cells.
10
Maris said MNK-795 sales could peak at $200 million by 2017.
11
Collectively, these results suggest that SEL201 has significant antileukemic activity and further underscore the relevance of the MNK pathway in leukemogenesis.
12
This approach will enable further rational structure-based drug design of new Mnk inhibitors and potentially novel ways of therapeutically targeting this kinase.
13
BMO Capital Markets analyst David Maris said MNK-795 sales could peak at $200 million by 2017.
14
Our results show that the activation of p38 and Mnk during MNV1 infection is important for MNV1 replication.
15
The crystal structure-guided design leverages stereoelectronic interactions unique to MNK culminating in a novel pyridone-aminal structure described for the first time in the kinase literature.
16
In this review the mechanisms of activation of MNK pathways by cytokine receptors are addressed and their roles in diverse cytokine-dependent biological processes are reviewed.