Significados de fetal hemoglobin em inglês

Current techniques for identifying fetal hemoglobin (HbF) inducers are complex and time consuming.

Stimulating the production of fetal hemoglobin may benefit patients with sickle cell anemia by inhibiting sickling.

Induction of fetal hemoglobin is a validated strategy to improve symptoms and complications of this disease.

Therefore, the goal of our study was to identify novel microRNA genes involved in fetal hemoglobin expression.

Of the four patients who did not develop increased fetal hemoglobin, three had only one cycle of therapy.

Pharmacologic stimulation of fetal hemoglobin (HbF) expression may be a promising approach for the treatment of beta-thalassemia.

We developed a unique bead-based strategy for the identification of inducers of fetal hemoglobin transcripts in primary human erythroid cells.

We further investigated the potential of fetal hemoglobin expression as a gender independent marker for automated identification of fetal cells.

These data support a mechanism of fetal hemoglobin activation by miR-34a involving STAT3 gene silencing.

Defining the latter may have important clinical implications for de-repressing fetal hemoglobin synthesis to treat sickle cell anemia and β thalassemia.

The biobanked cells were stratified on the basis of their baseline level of fetal hemoglobin production and exposed to fetal hemoglobin inducers.

In parallel effort, several classes of pharmacological agents that induce fetal hemoglobin expression through molecular and cell signaling mechanisms have been identified.

In the perinatal period, fetal hemoglobin is synthesized at high levels followed by a decline to adult levels by one year of age.

Univariate analysis of various biomarkers measured at enrollment showed that fetal hemoglobin (HbF) was the strongest prognostic factor of subsequent severe outcome.

These are primarily focused on correcting the defective beta-globin gene or editing the expression of genes or genomic segments that regulate fetal hemoglobin synthesis.

Resveratrol was shown to exhibit antioxidant activity and to stimulate the expression of the γ-globin genes and the accumulation of fetal hemoglobin (HbF).