Significados de regulatory subunit em inglês

In contrast to other ABC proteins, it serves as the regulatory subunit of an ion channel.

We hypothesized that early-onset lone AF is associated with mutations in the IKs channel regulatory subunit KCNE1.

Recent studies identified large number of gain of function mutations in the regulatory subunit of the channel which cause neonatal diabetes.

Here we describe the cloning and characterization of a regulatory subunit for Cdk5 known as p35.

Here, we report the unexpected finding of robust DNA-PKcs activation by N-terminal constraint, independent of either DNA or its regulatory subunit Ku.

Our data suggest that AtCBL1 may act as a regulatory subunit of a plant calcineurin-like activity mediating calcium signaling under certain stress conditions.

This raised the possibility that a Cdk5 regulatory subunit was responsible for the activation of Cdk5 in brain.

Our data provide evidence for a novel mechanism regulating the substrate specificity of a chromatin-modifying enzyme through disparate translational products of a regulatory subunit.

The decrease in activity of the PP2B correlated with down-regulation of PP2B catalytic and up-regulation of PP2B regulatory subunit expression.

These results suggest that scapinin is a putative regulatory subunit of PP1 and is involved in transformed or immature phenotypes of HL-60 cells.

These combined observations suggest that AKAP79 acts as a PP1 regulatory subunit that can direct PP1 activity toward specific targets in the AKAP79 complex.

PRKAG2 cardiac syndrome is an autosomal dominant inherited disease resulted from mutations in the PRKAG2 gene that encodes γ2 regulatory subunit of AMP-activated protein kinase.

Therefore, to target specific substrates, many phosphatases associate with distinct regulatory subunits and thereby modulate multiple cellular processes.

Using small angle X-ray scattering, the overall shape of the regulatory subunits and corresponding holoenzymes have been elucidated.

Taken together, these data suggest that physiological regulation of Arf-sensitive PLD may involve the coordinate assembly of several interacting regulatory subunits.

Recent studies have demonstrated that RyR are macromolecular complexes comprising of 4 pore-forming channel subunits, each of which is associated with regulatory subunits.