Caloric restriction stimulates the production of enzymes that appears to protect and rejuvenate mitochondria, the body's cellular power generators.

Drugs designed to rejuvenate mitochondria have shown promise in treating diabetes, and are celebrated as possible therapies for other conditions.

Rejuvenated mitochondria have also been observed in earlier studies of resveratrol's therapeutic and longevity-enhancing effects.

The exercise regimen prevented cognitive decline in aged rats, reduced oxidative stress, and rejuvenated mitochondria in the aged hippocampus.