Vaccines produced by using only the antigenic part of the disease causing organism.
1But safety concerns led to the introduction of so-called acellular vaccines in the 1990s.
2PT must be detoxified to be included in acellular vaccines, which results in conformational changes in the functional epitopes of PTs.
3The rate of pertussis infection was highest among 11- to 14-year-olds, who had only received acellular vaccines as children.
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