Significats de activate akt en anglès

We found regulated expression of activated Akt 1 in the mammary gland during involution.

However, our observation indicated that signaling changes induced by RTKIs could even activate Akt and induce the SP population.

Expression of constitutively activated Akt in the mammary glands of transgenic mice results in a delay in post-lactational involution.

Conclusion: These data suggest that API-59-OME may be a potent agent to target constitutively activated AKT pathway in ovarian cancer cells.

Activated AKT kinases provide a cell survival signal that may confer resistance to apoptosis induced by conventional therapies in cancer cells.

These results suggest that suppression of TGF-beta signaling by activated Akt is correlated with the development of tamoxifen resistance in breast cancer.

Our previous work showed the importance of activated AKT in mediating resistance of non-small cell lung cancer (NSCLC) to AZD6244.

These observations led us to examine expression of activated Akt 1 and bcl-2 family proteins in premalignant hyperplasias.

The resulting tumors were nesting positive and resembled a spectrum of glioma morphologies ranging in astrocytic character depending on cell-of-origin and presence of activated Akt.