Significats de active conformation en anglès

Kinetic analyses indicate that the protein promotes RNA folding to establish an active conformation.

The F104S mutation precludes the enzyme from achieving the active conformation and concomitantly binding peptide substrates.

ALP inhibited the conversion of the leukocyte beta2 integrins into an active conformation upon Fc receptor stimulation of granulocytes.

This alpha-helical, trimeric complex has been proposed to form the core of the membrane fusion- active conformation of the HIV-1 envelope.

Binding to the closed form is facilitated by an interaction with Asp195 in the WPD-loop, presumably stabilizing the active conformation.

The enhanced activation was suggested to be caused by tetranectin's ability to bind and accumulate tPA in an active conformation.

In addition to providing a useful template for further analogue synthesis, the study unequivocally determined the active conformation of the anilinopyrimidines.

The enzyme is bound to AMP-PNP and has an active conformation, whereas the substrate is empty and adopts an inactive conformation.

Structural and functional characterizations show how BRCC36 is switched to an active conformation by contacts with KIAA0157.

Self-splicing of the group I IVS from Tetrahymena thermophila rDNA is limited by the time required for the RNA to reach its active conformation.

These data suggest that the IPP complex rather than ILK plays an important role and supports integrin activation probably through stabilization of the active conformation.

The mutants, His-273 and His-175 p53, adopted the active conformation, with a dramatic decrease in the fraction of denatured protein.

The results further indicated that the position 28 and 59 may play certain roles in the correct folding of the active conformation.

Computational simulations of NtrC(R) in its active conformation further demonstrate that the rotameric state of Y101 is uncorrelated with the global conformational transition during activation.

Conclusions: SFKs are activated by different upstream signals to adopt multiple active conformations in cells.

This allosteric coupling may apply generally in organizing AAA+ protein translocases into their active conformations.