Significats de adaptational modification en anglès

Autophosphorylation in signaling complexes was measured as a function of ligand occupancy and adaptational modification.

Increased adaptational modification decreased helical dynamics while preserving dynamics differences among functional regions and between companion helices.

By the same assay, receptors modulate kinase activity -100-foldas a function of receptor ligand occupancy and adaptational modification.

In addition, higher order interactions among dimers are necessary for the observed patterns of assistance in adaptational modification among different receptors.

Yet, the enzymatic properties affected by incorporation into signaling complexes, by chemoreceptor ligand binding or by receptor adaptational modification are largely undefined.

To identify features important for functionally native receptor structure, we made Nanodiscs using natural and synthetic lipids, assaying extents and rates of adaptational modification.

We observed differences among functional regions, between companion helices in helical hairpins of the coiled coil and between receptor conformational states generated by adaptational modification.