Significats de affect sib en anglès

Such a locus could be detected in a realistic sample of affected sib pairs.

Factor score intraclass correlations were calculated using a subsample of 145 independent affected sib pairs.

Moreover, the mutations in the proband and its affected sib were co-segregated with the phenotype.

Non-parametric (genetic model independent) affected sib pair linkage analysis was used to evaluate evidence for linkage.

In addition, we tested genetic linkage to the SJS locus on chromosome 1 in one family with two affected sibs.

In both cases, thanks to the sharing of parental alleles in affected sibs, a refining of the modeling was obtained.

Six families were consanguineous, two had multiple affected sibs (males and females) and 4 families originated from the Middle East.

The multipoint identity-by-descent method is used to test for linkage through the qualitative trait, and for excess sharing of the chromosomal region among affected sibs.

To identify these inherited factors, linkage analysis of multiplex families is being performed on a sample of 105 families with two or more affected sibs.

In addition neither the 8p loci nor the 11q loci exhibit evidence of linkage to atopy by affected sib-pair analysis.