We investigated NGF gene transfer to the bladder and bladder afferentpathways for treating diabetic cystopathy.
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Conclusions: The NGF gene may be transferred and expressed in the bladder and bladder afferentpathways using HSV vectors.
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New afferentpathways have been discovered, as well as novel properties of previously known afferents such as the midbrain dopaminergic inputs.
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Background & aims: Cerebral evoked potential (EP) responses to visceral stimulation represent a powerful method to assess visceral afferentpathways.
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Some airway receptors mediate or influence cough through activation of vagal afferentpathways which converge on brain stem respiratory networks and of supramedullary centres.
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The cortical activity responsible for hallucinations results from altered or reduced input into these regions, or a loss of ascending inhibition of their afferentpathways.
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Recording of cerebral evoked responses (EP) allows the assessment of visceral afferentpathways and gut-brain communication, but the optimal stimulation parameters remain to be established.