Significats de aliphatic chain en anglès

Replacing this part of the molecule by an aliphatic chain (up to 4 C-atoms) leads to inactive compounds.

Additions of side groups such as small aliphatic chain increased the potency for channel inhibition, while additions of aromatic rings reduced it.

The results showed an increasing hydrolysis rate according to longest aliphatic chain, with a half-life of 24 days of the more stable acetate derivative (4a).

Most notably, an in-depth activity profile is reported for the most active subclass of derivatives that bear linear aliphatic chains off the amide bond.