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Significats de alkylating agent en anglès
Highly reactive chemical that introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning.
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Sinònims
Examples for "alkylators"
Examples for "alkylators"
1
HDAC inhibitors, DNA alkylators and nucleoside analogs are effective components of combination chemotherapy.
2
On the other hand, the use of alkylators and topoisomerase II inhibitors is associated with an increased risk of t-AML.
3
The protein level of MRP1 correlated with cellular resistance to busulfan and chlorambucil, and Rom exposure sensitized cells to these DNA alkylators.
4
To determine a possible mechanism of their synergism, we analyzed the effects of HDAC inhibitors on the expression of drug transporters which export DNA alkylators.
Ús de alkylating agent en anglès
1
All had previously received at least one purine analogue or alkylating agent.
2
The role of hyperthermia during regional alkylating agent chemotherapy is controversial.
3
Standard therapy for MM has been an alkylating agent and corticosteroid.
4
Thiotepa is an alkylating agent widely used in high-dose chemotherapy.
5
Treatment with this alkylating agent chemically compromises alkyl-DNA repair functions.
6
The discovery of the ATM-MPG axis will lead to improved treatment of alkylating agent-resistant tumors.
7
Treosulfan is an alkylating agent that has proven its indication in the treatment of e.g.
8
The mammalian enzyme but not the bacterial one was inhibited by a sulfhydryl alkylating agent.
9
Thus, SM exposure induces transcriptional changes that reveal the cellular response to this potent alkylating agent.
10
Discussion: Cyclophosphamide is an alkylating agent that has been associated with interstitial pneumonia and pulmonary fibrosis.
11
ID and cumulative incidence estimates were highest for patients who received both an alkylating agent and radiotherapy.
12
The reactivity of 13 potential cysteine conjugation sites in the antibody scaffold was tuned using a model alkylating agent.
13
The results demonstrate the massive differences in sensitivity across a diverse cell line panel exposed to an alkylating agent.
14
Animals were myelosuppressed with a single injection of the alkylating agent busulfan and subsequently treated with varying courses of calusterone.
15
The company said the decision was after a randomized Phase II study comparing anti-cancer drug AZD6244 monotherapy with an alkylating agent.
16
Importantly, combined inhibition or loss of MPG and ATM resulted in increased alkylating agent-induced cytotoxicity in vitro and prolonged survival in vivo.