Significats de allosteric modulation en anglès

We next tested the antiulcerogenic properties of CB 1 positive allosteric modulation.

These structures offer important insights into the activation mechanism and allosteric modulation of muscarinic receptors.

The cys-loop receptors also are subject to allosteric modulation by many pharmaceutical agents and endogenous modulators.

Thus, CB 1 positive allosteric modulation is a novel approach to treat cannabinoid dependence and gastric inflammation.

The Company is focused on developing drugs based on selective allosteric modulation of CNS synaptic and extrasynaptic receptors.

This series yielded a family of highly selective pharmacological tools that produced positive, negative and neutral allosteric modulation of mGluR5 activity.

Our results indicate a novel potential therapeutic strategy against glutamate cytotoxicity based on the positive allosteric modulation of A 1 ARs.

The mechanism of allosteric modulation is traditionally believed to be that allosteric modulators directly change the binding affinity of receptors for their agonists.

Amino acid residues necessary for pharmacologically relevant allosteric modulation of LGIC function by anesthetics and EtOH have been identified in these channel proteins.

Expert opinion: Dead enzymes have the potential to exert biological actions through protein-protein interaction and allosteric modulation of the activity of an active enzyme.

Because allosteric modulation can vary depending on the orthosteric ligand it is important to study their function in a system that employs endogenous cannabinoids.

Allosteric modulation of these class C 7-transmembrane spanning receptors represents a novel approach to facilitate development of mGlu subtype-selective probes and therapeutics.