Silica is a well-known occupational fibrogenic agent and its primary target cell is alveolarmacrophage.
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Less robust alveolarmacrophage recruitment and activation was observed in mice treated with intraperitoneal KGF.
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Strikingly, tissue interstitial macrophages were elevated in alveolarmacrophage-deficient mice identifying a new homeostatic relationship between different macrophage subtypes.
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Objectives: We recently determined in an animal model that alcohol ingestion impairs pulmonary zinc metabolism and causes alveolarmacrophage immune dysfunction.
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The objective of this research is to determine the effects of alcoholism on zinc bioavailability and alveolarmacrophage function in human subjects.
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In vitro and in vivo studies suggest that alveolarmacrophage produce the mediators implicated in the bone marrow response to ambient particles.
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In 13 patients presenting a defective CA of circulating PMNs, the in vitro response of alveolarmacrophage CA to r-IFN-gamma was also determined.
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One possible mechanism by which alcohol increases susceptibility to acute lung injury is through alterations in alveolarmacrophage function and induction of tissue remodeling activity.
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In this study, alveolarmacrophage DNA from heavy smokers and never smokers was isolated and methylation status at 25,000 loci determined.
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We provide evidence for the nature of inclusions contained in alveolarmacrophages.
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Significant gene expression changes in alveolarmacrophages from smokers have been identified.
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This study reveals a novel mechanism of bacterial clearance by alveolarmacrophages.
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Resident alveolarmacrophages are important in host defense against opportunistic fungal infections.
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PMT-derived alveolarmacrophages persisted for at least one year as did therapeutic effects.
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Legionella pneumophila proliferates within alveolarmacrophages as a central property of Legionnaires' disease.
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Small vesicles containing gold particles were found in the cytoplasm of alveolarmacrophages.