Significats de angiogenic sprouting en anglès

During new blood vessel formation, the cessation of angiogenic sprouting is necessary for the generation of functional vasculature.

Loss-of-function studies in the zebrafish and mouse point to a specific role for Syx in angiogenic sprouting in the developing vascular bed.

PHD4 overexpression in tumor cells stimulated the expression of TGF-a, which was necessary and sufficient to promote angiogenic sprouting of endothelial cells.

Importantly, a profile consisting of a high VEGF concentration initially, followed by a decreasing concentration over time was found to yield optimal angiogenic sprouting.