This finding led us to hypothesize that a conserved structural basis of antigenicescape from anti-AMA-1 exists.
2
Here, we describe the evolution of antigenicescape variants in a rhesus macaque that developed unusually high neutralizing antibody titers to SIVmac239.
3
By using an in vitro model of antigenicescape, the inhibitory contribution of 24 polymorphic sites of the 3D7 AMA-1 vaccine was determined.