Significats de apoptin en anglès

However, the mechanisms through which apoptin achieves its selective killing effects are not well understood.

Death susceptibility correlated with increased phosphorylation and activation of the apoptin protein in MM1.R cells.

Thus, apoptin treatment represents a potential method for enhancing the effectiveness of radiotherapy in poorly responding hepatocellular carcinoma.

Our findings are also the first to show that the combination of radiation and apoptin up-regulates p53 expression.

Our previous study showed that chicken anaemia virus-derived apoptin protein induced the apoptosis of hepatic carcinoma HepG2 cells.

In tumour cells, but negligibly in normal cells, apoptin is imported into the nucleus prior to the induction of apoptosis.

Further, they highlight the potential of apoptin and its cellular regulators to purge bone marrow used in autologous transplantation for multiple myeloma.

The chicken anemia virus-derived protein apoptin induces apoptosis in a variety of human malignant and transformed cells but not in normal cells.

In the present study, we demonstrated that apoptin sensitizes cells to radiation-induced apoptosis using a lentivirus-apoptin expression system in hepatic carcinoma HepG2 cells.

In addition, dexamethasone-resistant MM1.R cells were found to be more susceptible to apoptin-induced cell death than the parental matched MM1.S cells.

These superstructures do not grow beyond a diameter of approximately 200 nm, containing up to 20 multimeric apoptin complexes and approximately 3 kb of DNA.

Moreover, MT23-Apoptin can significantly inhibit tumor growth and induce the cell apoptosis in B16 tumor bearing mice.

Apoptin's preference for these DNA-dense nuclear bodies may be explained by our finding that apoptin cooperatively forms distinct superstructures with DNA in vitro.

However, the mechanisms through which apoptin achieves its selective killing effects are not well understood.

Death susceptibility correlated with increased phosphorylation and activation of the apoptin protein in MM1.R cells.

Thus, apoptin treatment represents a potential method for enhancing the effectiveness of radiotherapy in poorly responding hepatocellular carcinoma.