Significats de autophagic response en anglès

Compromised ability to activate the autophagic response may underlie some common ciliopathies.

We have shown previously that hemodynamic load elicits a maladaptive autophagic response in cardiomyocytes which contributes to disease progression.

In some settings, the autophagic response is beneficial and pro-survival; in other contexts, it is maladaptive and promotes disease progression.

Here, we hypothesize that LOX-1 expression in EC represents a crucial event which attenuates protective autophagic response, thereby enhancing programmed endothelial cell death.

In addition, we summarize how corneal Herpes Simplex Virus (HSV-1) infection subverts the cornea's response to infection by inhibiting the normal autophagic response.