Significats de axonal transport en anglès

Collectively, the data provide a biological basis for Aβ-induced axonal transport deficits.

Recent studies suggest that axonal transport of mitochondria along microtubules is disrupted in ALS.

Thus, synapsin I does not appear to inhibit the fast axonal transport mechanism itself.

In addition, beta-amyloid precursor protein staining indicated impaired axonal transport.

This enzyme deacetylates microtubules and plays a crucial role in the regulation of axonal transport.

Excess of non-functional GSK-3β did not affect axonal transport.

We studied slow axonal transport and morphometry of forelimb axons in wobbler mice and controls.

Kinesin is believed to generate force for the movement of organelles in anterograde axonal transport.

Spheroids demonstrated increased immunoreactivity to amyloid precursor protein and neurofilament indicating probable impairment of axonal transport.

Surprisingly, however, this combination suppressed rather than increased APP-induced axonal transport defects in both Drosophila and mice.

In addition, we summarize the therapeutic approaches targeting the axonal transport machinery in studies of neurodegenerative diseases.

Synaptic vesicles apparently retain the capacity for fast axonal transport, even after they reach their intracellular destination.

We propose that the axonal transport impairment may be a deleterious consequence of accumulated, toxic MAP8 protein.

Recent work indicates that in many neurodegenerative diseases long distance axonal transport is perturbed, leading to axonal blockages.

Previous studies have provided compelling evidence that conventional kinesin is a major motor for anterograde fast axonal transport.

Although previous studies have demonstrated Aβ-induced transport blockade, early effects of low-n soluble Aβ-oligomers on axonal transport remain unclear.