Significats de based vectors en anglès

We also generated HCMV- based vectors that express E6-derived peptide fused to HCMV proteins.

Continued improvements in luciferase- based vectors and measurement reagents confer considerable versatility.

On the other hand, AAV2- based vectors can be readily purified by heparin column.

The implications for development of DIS-modified retrovirus- based vectors are discussed.

Over the past decade, AAV- based vectors have emerged as promising candidates for gene therapeutic applications.

The findings are relevant to future preclinical and clinical airway gene therapy trials using lentivirus- based vectors.

DNA-encoded miRNA inhibitors expressed from plasmid or virus- based vectors provide persistent miRNA suppression and options of tissue-directed micromanaging.

These findings indicate promise for RV- based vectors and have important implications for the development of an efficacious HIV vaccine.

Despite the broad tropism of the first eight serotypes identified, certain cell types are refractory to transduction with AAV- based vectors.

Importance: Rabies virus- based vectors have been proven to be efficient dual vaccines against rabies and emergent infectious diseases such as Ebola virus.

By exploiting this property, the efficiencies of cellular binding and internalization of lipid- and polymer- based vectors were studied and correlated to their transfection efficiencies.

The findings presented here lay the foundation for clinical development of HBoV1 capsid- based vectors for lung gene therapy in cystic fibrosis using ferret models.

Along with its robust transduction efficiency, our findings support the continued development of AAV8- based vectors for clinical applications in humans, especially for tumor gene therapy.