But in addiction, the theory goes, the circuits can become uncoupled, so that you get extreme wanting without a corresponding increase in pleasure.

The first patrol cars braked dangerously close to people on the edge of the main crowd, as if their safety systems had somehow become uncoupled.

The coach became uncoupled and Baldwin seized a lantern in an effort to signal a passenger train following.

These two components subsequently became uncoupled with respect to timing, placement within the sclera and inductive epithelia, enabling them to evolve independently and to diversify.