EZH2 is involved in malignant transformation and biological aggressiveness of several human malignancies.

There are few reliable prognostic markers of biological aggressiveness for head and neck carcinomas in general.

In this context, 67kDa-laminin receptor appears to be a marker for biological aggressiveness of human lung cancer.

This fact indicates, they can reflect the common biological aggressiveness of tumor and need not to be tamoxifen specific.

Among them, steroidogenic factor 1 deserves major interest because of its potential usefulness as a marker of adrenocortical derivation and of biological aggressiveness.

These observations suggest that matriolytic enzymes in renal cystic fluid reflect biological aggressiveness and in part explain the pathogenesis of renal cystic lesions.