These efforts may also be aimed at maintaining metabolic health throughout life by targeting brownadipocyte function.
2
Here we tested whether TENM2 deficiency in adipocyte progenitor cells would lead to a brownadipocyte phenotype.
3
Primary brownadipocyte cultures in vitro confirmed that miRNAs are required for marker gene expression in mature brown adipocytes.
4
We here review the available literature on the potential mechanisms leading to cell-autonomous and microenvironment-related aspects of brownadipocyte dysfunction.
5
We define critical settings required for adipocyte flow cytometry and provide a rigid strategy for analyzing and sorting white and brownadipocyte populations.
6
In conclusion, Nrf1 emerges as a novel guardian of brownadipocyte function, providing increased proteometabolic quality control for adapting to cold or to obesity.
7
Taken together, this study indicates that indomethacin can promote mouse brownadipocyte differentiation, and might increase brown fat and glucose oxidation capacity in DIO mice.
8
Two distinct types of fat cells are known: White and brownadipocytes.
9
Here we report on secretion and hormonal regulation of leptin by brownadipocytes.
10
This molecular probe is a new, sensitive and reliable tool with which to study human brownadipocytes.
11
Using isotopic labeling experiments, we found that activated brownadipocytes increased labeling of pyruvate and TCA cycle intermediates from U13C-glucose.
12
Recent studies have demonstrated that brownadipocytes also secrete factors that act locally and systemically to influence fuel and energy metabolism.
13
The uncoupling protein (UCP) gene encodes a unique mammalian mitochondrial proton carrier that induces heat production in brownadipocytes.
14
Taken together, our study demonstrates an essential role of miRNAs in the maintenance as well as in the differentiation of brownadipocytes.
15
White adipocytes are plastic cells able to reversibly transdifferentiate into brownadipocytes and into epithelial glandular cells under physiologic stimuli in vivo.
16
Importantly, BAT content and activity decline in obese subjects, mainly as a result of the conversion of brownadipocytes to white-like unilocular cells.