Significats de canonical nf en anglès

Recent studies have highlighted the importance of dynamic ubiquitination-deubiquitination events in regulating this canonical NF-kappaB signaling pathway.

The mechanism of this barrier dissolution and its relationship to the canonical NF-kB pathway remain poorly defined.

Therefore, IKKβ, the key regulatory kinase of the canonical NF-kB pathway, should be a logical target for cancer treatment.

We propose that our new CLL-like mouse model represents an appropriate tool for studying ubiquitination-driven canonical NF-kB activation in CLL.

The tumor suppressor Par-4 is an important negative regulator of the canonical NF-kappaB pathway and is highly expressed in prostate.

Here we show that HOIPINs down-regulate not only the proinflammatory cytokine-induced canonical NF-kB pathway, but also various pathogen-associated molecular pattern-induced antiviral pathways.

We showed that JFK-mediated ING4 destabilization leads to the hyperactivation of the canonical NF-kB pathway and promotes angiogenesis and metastasis of breast cancer.

The scaffold proteins Bcl-10 and MALT1 couple antigen-receptor signals to the canonical NF-kappaB pathway and are pivotal in lymphomagenesis.

Our results provide mechanistic insights into B cell receptor-induced survival and proliferation signals and demonstrate the selective control of c-Rel in the canonical NF-kappaB pathway.

We propose that elevated levels of sCLU promote prostate cancer cell survival by facilitating degradation of COMMD1 and I-kappaB, thereby activating the canonical NF-kappaB pathway.