Significats de cardiac ion en anglès

Objective: Genetic variants of cardiac ion channels may influence cardiac repolarization.

In conclusion, Cav-3 OE mice have changes in ECG intervals, heart rates, and cardiac ion channel expression.

Background: Many studies revealed that variations in cardiac ion channels would cause cardiac arrhythmias or act as genetic risk factors.

Multiple mutations in five genes encoding structural subunits of cardiac ion channels now have been identified in families with LQTS.

We assessed the suitability of the P19 cell model for studying cardiac ion channel regulation at the molecular and functional level.

We hypothesized that specific single nucleotide polymorphisms in cardiac ion channels were associated with cardiac rhythm disturbance in the Chinese population.

Conclusion: Cardiac differentiation of mouse embryonic stem cells is characterized by a sequential upregulation of the main cardiac ion channels and connexins.

These approaches may target traditional and newly discovered cardiac ion channels, as well as new molecular and signaling pathways that modulate arrhythmic substrates.

Currently, it is unclear if disease-associated CASQ2 gene variants alter intracellular free Ca(2+) concentrations and if cardiac ion channels are affected by it.