Deregulated expression of G1 cyclins and their cognate cdk partners is often found in human tumor cells.
2
These findings argue against the proposed necessity of complete Rb inactivation by sequential phosphorylation by D- and E-type cyclin-cdk complexes.
3
We have studied the role of a conserved hydrophobic patch on the surface of cyclin A in substrate recognition by cyclin A-cdk2.
4
In addition, the concomitant expression of Np95 and of cycE-cdk2 was alone sufficient to induce S phase in TD cells.
5
Shortening of G1 phase temporally correlated with more rapid degradation of the cdk inhibitor p27Kip1 and with premature activation of cyclin A-dependent cdk2.
6
In March, CDK named Brian MacDonald as the company's new chief executive.
7
Chronic antidepressant treatment did not affect the expression of other Cdk inhibitors.
8
When CDK spun out from Automatic Data Processing Inc last year, activists pounced.
9
A private equity deal for CDK could be this year's largest leveraged buyout.
10
CDK Global was spun off from Automatic Data Processing Inc ADP.O in 2014.
11
Cyclin D1 mediates this activation independent of complex formation to a CDK partner.
12
However, the increased CDK activities were not sufficient to effect mouse skin tumor development.
13
Yet, these antiviral effects could result from inhibition of either cellular cdks or viral enzymes.
14
In addition, CA dramatically reduced the activity of CDKs.
15
Elliott did not provide a comment, while CDK and Morgan Stanley also declined to comment.
16
CDK, based in Hoffman Estates, Illinois, has been under pressure from Elliott since May 2015.