Significats de cerebellar granule en anglès

These experiments suggest that endogenous transmitter activates NMDA-receptors in cerebellar granule cells in culture.

Intact cerebellar granule neurons in primary culture rapidly accumulate AEA.

Here we examined the effects of type 1 diabetic serum on primary cerebellar granule cells (CGCs).

Previous studies have established that the neuronal protein astrotactin functions in murine cerebellar granule cell migration in vitro.

Here we show that glutamate can induce either early necrosis or delayed apoptosis in cultures of cerebellar granule cells.

Among CNS neuronal populations, the cerebellar granule cell provides a simple model for analysing the molecular regulation of CNS neurogenesis.

Our findings indicate that a noradrenergic influence may be necessary for the normal maturation and migration of cerebellar granule cells.

Fab fragments of antibodies to a recombinant astrotactin peptide blocked migration of cerebellar granule neurons in vitro along astroglial fibers.

The present findings indicate that apoptosis plays a major role in the neuronal loss of the cerebellar granule cells in CJD.

These data suggest that in cerebellar granule cells in culture, both L-HC and D-HC activate the same NMDA receptor channel complex.

In cultured cerebellar granule cells and in freshly isolated hippocampal pyramidal cells arachidonic acid decreased the current produced by iontophoresed AMPA.

NFIX is expressed by progenitor cells within the external granular layer and by cerebellar granule neurons within the internal granule layer.

In primary cultures of cerebellar granule neurons, BDNF-induced reduction of TrkB receptors was largely prevented by the addition of specific proteasome inhibitors.

Frequent p62-positive neuronal inclusions were present in cerebellar granule neurons as is typical of C9ORF72 mutation carriers.

We also show that Dp5 and other BH3-only proteins kill cerebellar granule neurons in a Bax-dependent manner.

These results suggest that AEA is accumulated by cerebellar granule cells by a protein-mediated transport process that has the characteristics of facilitated diffusion.