Significats de chemical carcinogens en anglès

Fetal mice are more sensitive to chemical carcinogens than are adults.

Aromatic amines constitute one of the most extensively studied classes of chemical carcinogens.

P450 activity is required to metabolically activate many chemical carcinogens, rendering them highly genotoxic.

Meyer inhibited carcinogenesis induced by several chemical carcinogens in 1978.

The 10% of the examined workplaces showed a possible exposure to chemical carcinogens.

These studies define the relative contributions of individual P450 forms to the activation of various chemical carcinogens.

The results show that activated ras genes can replace chemical carcinogens in initiation of mouse skin carcinogenesis.

However, the role of CYP3A4 in activating chemical carcinogens into potent genotoxins is unclear.

A putative association between obesity and colon tumorigenesis has been explored experimentally using chemical carcinogens administered to obese rodents.

Background: Interindividual genetic differences in susceptibility to chemical carcinogens are among the most important host factors in human cancer.

General significance: We propose a new mechanism for RRM2 regulation to maintain genome stability in response to environmental chemical carcinogens.

Most chemical carcinogens require metabolic activation to electrophilic metabolites that are capable of binding to DNA and causing gene mutation.

Current regulatory practices for chemical carcinogens were established when scientific understanding of the molecular mechanisms of chemical carcinogenesis was in its infancy.

Further, the results suggest that other genetic factors may interact with chemical carcinogens in determining individual susceptibility to these agents during development.

Polycyclic aromatic hydrocarbons (PAH) are a class of chemical carcinogens whose active metabolites form DNA adducts, resulting in specific mutational events.

Anurans seem to have a greater frequency of spontaneous neoplasms than do urodeles and respond to chemical carcinogens in a manner analogous to mammalian species.